Tag: Histone –
Transient deletion of hypermutation preserves B cell affinity
We showed that large clusters of MCherry-expressing Histone-2b (H2b-mCherry) cells are enriched in GC B cells carrying affinity-enhancing mutations. Here, we observed that DZ B cells remained above the CDK2Low G0 threshold at 36 h after anti-DEC-OVA treatment and C-N ratios in DZ B cells remained steadily above the CDK2low G0 threshold within 30 min of anaphase.
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