Latest News
Clinical classification of the BRCA2 variant is based on genome editing
A machine learning-based algorithm has been used to predict the risk of breast and ovarian cancer in women with BRCA2 variants, based on genome-wide transcriptome data. A computational model was used for classification of BRCA2 variants using mouse embryonic stem cell-based functional assays. Genetic variants in BRCA2 are associated with breast cancer and ovarian cancer, respectively.
Read More
There is a foundation of transcription for human cell types
A model was used to learn regulatory grammar in the GET architecture using chromatin accessibility data from a variety of human cell types. The model was trained on the fetal accessibility and expression atlas and was able to complete in 8 h. It is possible to perform large-scale screening with the help of inference for genes in a single cell type.
Read More
embryo editing against disease is unsafe and is not proven
Researchers from Australia, China and the US have examined the possibility of editing genomes of human embryos in the future. They found that in some cases, editing a single variant associated with a polygenic disease can have strong effects and that editing up to ten genes associated with a disease can reduce its lifetime prevalence by an order of magnitude.
Read MoreWinter illnesses return with a vengeance
Human metapneumovirus (hMPV) has a seasonal spike in the US after the first outbreak. While hMPV levels in the US are currently low, it accounts for less than 2% of weekly positive tests for respiratory viruses, based on CDC’s latest data. The country also experienced a sudden post-pandemic jump in hMPV infections during the winter of 2022-23.
Read More
Las Vegas police released logs from the crime scene of the Cybertruck explosion
Matthew Livelsberger, an Army Green Beret with two deployments in Afghanistan, was investigating the New Year’s Eve explosion in front of the Trump Hotel in Las Vegas using generative AI technique, according to the police. Livelsberger had left a note that said the explosion was designed to be a “wake-up call” for the nation’s troubles. Livelsberger died in the explosion.
Read MoreIt has been a challenge trying to prevent vehicular attacks
A man who rammed into a crowd of people on New Year’s Day in New Orleans,Louisiana had used “smart glasses to record a video”, the FBI said on Sunday. The man was in the area before and used “smart glasses” to record video, it added. He had also visited New Orleans twice to do surveillance, the FBI further said.
Read MoreA storm will bring dangerous ice and snow to the east coast
The US State Department has advised the public to avoid travel in affected areas as a winter storm is expected to hit parts of the country. The National Weather Service (NWS) has issued winter weather warnings and advises people to stay indoors and not travel if they are in the storm’s path. The storm is expected to begin on Saturday and continue till Monday.
Read MoreAccording to the sheriff, cybertruck driver may have killed himself with a gunshot to the head
FBI Deputy Assistant Director Chris Raia has said there is nothing to indicate that the explosion in Las Vegas was carried out by anyone. He added that investigators are combing through five electronic devices, three cellphones and two laptops. “There’s an unprecedented amount of law enforcement resources…being utilised to finalise the investigation,” Raia further said.
Read MoreThere is a Cybertruck parked outside of the Las Vegas hotel
Elon Musk has said that the explosion in a Tesla vehicle in Las Vegas was caused by large fireworks and a bomb carried in the bed of the vehicle itself. He added, “We have now confirmed that the explosion was caused by very large fireworks and or a bomb carried in the bed of the rented Cybertruck and is unrelated to the vehicle itself.”
Read More
Neural crest-like cells are what cause glomagenesis to mimic an injury response
The first-ever cluster-centric analysis of brain stem cell datasets using the inferCNV package was used to identify clonal regions. Raw sequencing data from the 30 scRNA-seq samples and low-quality cells were aligned to mm10 mouse reference using Cell Ranger. Doublet and multiplets were identified by scDblFinder, and low-quality cells were removed as part of the quality control process.
Read More