Category: Uncategorized
According to the European climate agency, Earth is on track for its warmest year yet
The average temperature in September was 0.93C above the 1991-2020 average for September, making it the warmest month since Copernicus Climate Change Service started keeping records 83 years ago. Earth is on track for a warmest year ever, with an average temperature of about 2.5C hotter than pre-industrial times. The global threshold goal of 1.5C is for long-term temperature averages.
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The UK Biobank has rare variant associations with plasma protein levels
We identified all variants reported in the NHGRI-EBI catalogue of human GWAS74 in high LD with sentinel pQTLs based on UKB-BI data and Icelandic SomaScan data. In addition to high LD between the disease-associated variant and both the pQTL and a variant in the credible set, we estimated the posterior probability of statistical colocalization for the variants associating with disease and protein levels when they were not identical.
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Large-scale comparisons of genes and diseases
To determine the colocalization of coronavirus variants, we identified a 95% credible set of variants likely to include the causal variant76. We identified primary associations through clumping 1 Mb around the significant variants using PLINK60. An enrichment analysis hypergeometric test was performed to estimate enrichment of the associated pQTL variants in specific consequence or regulatory genomic regions.
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SBF on trial: Is he a math nerd or was his empire built on lies?
Former FTX CEO, Sam Bankman-Fried, on Monday pleaded not guilty to seven charges of fraud and money laundering. Bankman-Fried is facing trial in New York for allegedly running a Ponzi scheme and defrauding customers, investors and lenders by selling stock in FTX and borrow millions from lenders by lying. Bankman-Fried’s former roommate Adam Yedidia also testified at the trial.
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The pioneers of vaccine invention won the medicine portion of the prize
Katalin Karik and Drew Weissmann have won the 2009 Nobel Prize in Physiology or Medicine for their discoveries that enabled the development of COVID-19 vaccines. “The ideas [that] she and Drew Weismanndeveloped were critical for the success of RNA vaccines,” said John Tregoning, a vaccine immunologist at Imperial College London, in a press statement for the UK Science Media Centre.
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Many just walked out of the pharmacy because they had a complaint about it
Nurses, lab technicians, pharmacists and therapists at hospitals, clinics and medical offices across the US are planning to strike for three days starting April 25. The unions are demanding that the health-care giant provide raises of up to 14%, which they claim is “far below” what’s needed. They’re also claiming that they’re being underpaid and not getting the quality of care they deserve.
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The Charge 6 fitness tracker is built in to the internet
Fitbit has unveiled the Charge 6 heart rate monitor and fitness band with built-in GPS, GLONASS, among others. The device features “the most accurate heart rate sensing of its fitness bands”, Fitbit said. It includes an optical heart rate monitor, accelerometer, built-in GPS and GLONASS, SpO2 temperature sensor, and other sensors for stress tracking and advanced heart health alerts.
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There is a search for a connection between asthma and the respiratory syncytial virus
Researchers at the University of Wisconsin-Madison have found that a vaccine for the lung infection RSV can elicit a potent response from helper T cells that recruit other immune cells during infection. The vaccine, developed by the UW-Madison, appears to be effective against coronavirus but not against the other strains. It is currently being tested as an emergency backup for children aged 3 years and above.
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The work begins now that the treatments are here
A study found that older adults over the age of 65 with underlying health conditions were between 1.2 to 28 times more likely to be hospitalised than adults without an underlying condition. It also found that those with at least one underlying medical condition were nearly 95% less likely to be hospitalised than those without an underlying condition.
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Antibody therapies are being developed to prevent respiratory syncytial virus in babies
The burden of respiratory viral disease in low and middle-income countries (LMICs) is too big or too small, said Maria Zambon, director of infectious diseases at the UK health security agency. In high-income countries, the prices of the antibodies will be between $300 and $500 for infants, which is not much more than the cost of a vaccine for RSV.
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