Scientists are editing the genes of gutbacteria in mice
An experimental study of genetic edits that make oestrogen bones stronger and stronger when injected into a mouse model of breast milk
Several research teams have attempted to make genetic tweaks to gut bacteria in mice, but achieving this inside the body has been challenging. 4, 3. In the past, base editors have failed to modify enough of the target population to be effective because they did not break the DNA double strand. They were delivered in a specific way that is not common in the lab.
The next step for Duportet and his colleagues is to develop mouse models with microbiome-driven diseases to measure whether specific gene edits have a beneficial impact on their health.
It’s important to note that bones are stripped of calcium while levels of oestrogen plummet during breastfeeding. This puts bones under tremendous stress, but why they don’t break down at this time has proved a mystery. The team has found a hormone that help build up bones in mice and make them stronger when producing milk. The team hopes that injecting this hormone into injured mice helped their bones heal faster, and will help treat osteoporosis in humans.
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Researchers have found a hormone that helps build up bones in mice and make them stronger when producing milk. They injected the hormone into injured mice, and they found that it helped them heal faster. They hoped that injecting this hormone into injured mice helped their bones heal faster, and will help treat osteoporosis in humans.